Welcome to the openGUTS information pages
OpenGUTS is a user-friendly
software to perform analyses with GUTS: the General Unified
Threshold model for Survival. GUTS is the leading
toxicokinetic-toxicodynamic framework for the endpoint
survival (and other non-reversible all-or-nothing effects).
Version 1.0 was released in December 2019, followed by
Version 1.1. in February 2021.
This site hosts the software itself, as a standalone Windows
executable, with manuals and background documentation. Since
openGUTS is (as the name implies) open source, also the
source files can be obtained here. Additionally, you can
download the Matlab version, which served as the blueprint
for the standalone version. The Matlab version has basically
the same functionality, and can be easily adapted or
extended to perform customised analyses. Finally, we provide
(links to) further information on openGUTS and GUTS.
The main features of the software are:
- Open and free: the software is open source and
freely downloadable. The fully-functional Matlab version that
served as the prototype is also available.
- User-friendly: fit models and derive
confidence intervals without requiring user interaction
(e.g., no need for starting values).
- Robust: always find the global optimum and
relevant intervals, even for awkward data sets.
- Flexible: allow time-varying exposure, missing
data, simultaneous fitting on multiple data sets, etc.
- Efficient: rapid screening of exposure profiles
output) by batch processing.
- Supportive: the software follows the workflow
as laid down in the 2018
EFSA opinion on TKTD models.
in v1.0. The IT calculations use a shortcut
that does not work in all cases. This error will affect IT calibrations
for time varying exposure, where the exposure scenario
includes episodes of linear decrease over time (for constant
exposure and block pulses, it will be fine). It will also
affect IT LPx predictions when the exposure
scenario is specified with a crude resolution (the hourly
resolution of FOCUS profiles will lead to negligible
errors). This error is repaired in the update of the Matlab
version, to v. 1.1. Download a PDF
document explaining this error in detail. (posted
19 May 2020). This error is repaired in the update of
the standalone and Matlab version, to v. 1.1.
New version of the
standalone launched (v1.1). The openGUTS
standalone has been updated: the error has been fixed and
extended batch capabilities have been included.
openGUTS standalone Windows executable
openGUTS in Matlab
- 25 February 2021: Version 1.1 of the openGUTS
standalone has been released. See download
page. Over the next days, the downloads for the
manual and source code will be updated as well.
- 12 February 2021: The paper on the openGUTS algorithm
is now available in final format, and included into a
- 9 January 2021: Best wishes for the new year! Forgot
to provide the link to the new paper on the algorithm
used in openGUTS for calibration and error propagation.
It is still only available in 'early view': DOI:
- 29 August 2020: The general statistical framework and
the automated optimisation algorithm as developed for
openGUTS have been described in detail in a manuscript,
including an extensive supporting information. This
manuscript has been accepted for publication in IEAM; a
link will be provided here when the paper is available
- 26 May 2020: update of the Matlab version of openGUTS.
This version 1.1 repairs the error that was discovered
(the standalone still has this error, so do take a look
at the dedicated document for this error). See download page.
For old news items, click here.